Key analytical methods used in our laboratory is a high-performance liquid chromatography with tandem mass spectrometry detection (HPLC-MS/MS) and ELISA. The methods are highly-productive and is characterized by high sensitivity and selectivity of detection.

The studies are performed with analytical equipment from leading manufacturers — Shimadzu, Thermo Scientific and Adaltis S.r.l.:

• Shimadzu LCMS-8060
• Shimadzu LCMS-8050
• Thermo TSQ Quantum Ultra
• Personal LAB

Liquid tandem mass spectrometers Shimadzu LCMS–8060 ara characterized by the utmost level of performance and high-speed operation. Innovative system of ionic optics UF-Qarray focuses the ion flux and together with the ionization source with heated gas and improved vacuum-pumping system provides significant increase of signal intensity from target ions. Signal-to-noise ratio, which is equal to 180 000:1, makes the model LCMS-8060 one of the most sensitive liquid tandem mass spectrometers at the moment.

To measure the concentrations of high-molecular compounds are used the automated immunoassay analyzers Personal LAB manufactured by Adaltis S.r.l.

The distinctive features of the Personal LAB analyzers are full automation of all procedures, universality with respect to the types of test systems used and the programming of the analysis process, the specification of report forms and integration with laboratory information systems. Automation and programming procedures can significantly increase the productivity of the work, unify the procedure for conducting analyzes and eliminate possible errors associated with performing operations in manual mode. The technical features of the analyzer include detection with a sixteen-channel photometer with a wavelength range of 400-700 nm, the presence of high-precision syringes, liquid level sensors, capacitive and pneumatic sensors in the dosing system, automatic sample dilution, provision of protection against contamination of the system, with images with high optical density.

The laboratory is equipped with a wide array of devices for the most extensive range of tasks:

• water purification system Direct-Q3 UV
• centrifuges Eppendorf and ELMI (including the option of sample refrigeration)
• refrigerators and freezers (including deep-freeze refrigerator that provides storage of biological samples at a temperature below –70°С)
• mechanical and electronic high precision pipettes, Sartorius and Eppendorf
• analytical balance
• high-speed shaker for plates and test tubes

The laboratory performs all basic methods of sample preparation:

• protein precipitation
• solid phase extraction
• liquid-liquid extraction

In its work the laboratory uses only certified reagents recommended for chromatographic analyses.

We have installed no-break power supply systems and isolated electric diesel generator against the possibility of electrical power outage.